There are various methods for treating advanced hepatocellular carcinoma with portal vein invasion, such as systemic chemotherapy, transarterial chemoembolization, transarterial radioembolization, and concurrent chemoradiotherapy. These methods have similar clinical efficacy but are designed with a palliative aim. Herein, we report a case that experienced complete remission through “associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)” after concurrent chemoradiotherapy and hepatic artery infusion chemotherapy. In this patient, concurrent chemoradiotherapy and hepatic artery infusion chemotherapy induced substantial tumor shrinkage, and hypertrophy of the nontumor liver was sufficiently induced by portal vein ligation (stage 1 surgery) followed by curative resection (stage 2 surgery). Using this approach, long-term survival with no evidence of recurrence was achieved at 16 months. Therefore, the optimal use of ALPPS requires sufficient consideration in cases of significant hepatocellular carcinoma shrinkage for curative purposes.
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Is multidisciplinary treatment effective for hepatocellular carcinoma with portal vein tumor thrombus? Won Hyeok Choe Journal of Liver Cancer.2022; 22(1): 1. CrossRef
In hepatocellular carcinoma (HCC), sorafenib is the only approved systemic chemotherapy,
and has been applied for those with advanced HCC especially with systemic metastasis.
However, the treatment results are suboptimal leaving many cases with disease progression
despite the use of optimum dose. There is no established guideline for those that fail to
respond to sorafenib treatment. In this case, a 46-years-old male with metastatic lung cancer
from HCC experienced progression despite sorafenib treatment. Then, the patient received
surgical resection of the metastatic lung mass followed by radiation therapy and achieved
complete remission for 10 months after the surgical treatment and radiation therapy.
Alpha-fetoprotein level was normalized and complete remission has been maintained.
Trans-arterial chemoembolization (TACE) is widely used in the treatment of unresectable hepatocellular carcinoma (HCC). Its common complications are right upper quadrant pain, nausea, vomiting, whereas some rare complications include focal pancreatic necrosis, gastric ulcer, renal failure, DIC, biliary tree necrosis and splenic infarction. Bronchobiliary fistula (BBF) is a rare complication that consists of the formation of a passageway between the biliary system and the bronchial tree. We report a case of BBF due to previous TACE for HCC.
Byoung Wook Bang, Seok Jeong, Yong Sun Jeon, In Suh Park, Don Haeng Lee, Jung Il Lee, Kye Sook Kwon, Hyung Gil Kim, Yong Woon Shin, Young Soo Kim, Jin-Woo Lee
Journal of the Korean Liver Cancer Study Group. 2008;8(1):74-76. Published online June 30, 2008
A hepatocellular carcinoma (HCC) invading the bile duct is an uncommon form and sometimes difficult to
differentiate from cholangiocarcinoma. Because of different treatment modality, differential diagnosis of thesetwo
diseases should be performed. We experienced an unusual case with HCC with obstructive jaundice caused by the
involvement of intrahepatic duct, then confirmed by percutaneous transhepatic cholangioscopic biopsy results. A
60-year-old man was admitted with fever, chills, and an epigastric pain of 5 days duration. The patient had
compensated liver cirrhosis as a result of alcohol abuse. Multidetector computed tomography (MDCT) of the
abdomen revealed a low attenuated mass associated with bile duct dilation at the fourth segment of the liver. The
cholangioscopic finding showed a single, 2-cm, polypoid mass with a yellowish ‘‘chicken fat-like’’ appearance,
protruding into the lumen of the fourth branch of the left intrahepatic duct and bleeding easily. A diagnosis of
HCC was proven by microscopic examination of the tissue specimen obtained by a cholangioscopic biopsy.